A new screening tool, digital tomosynthesis (3D mammography), is available in some areas. This technology provides more detailed, three-dimensional images, improving cancer detection in dense breast tissue.
Ultrasound
A breast ultrasound uses sound waves to create images of the breast. It is often used alongside a mammogram to:
- Evaluate breast lumps or abnormalities
- Distinguish between solid tumours and fluid-filled cysts
- Guide a biopsy
Breast MRI (Magnetic Resonance Imaging)
A breast MRI uses magnetic fields and radio waves to create detailed, three-dimensional images of the breast. It does not use radiation and is used to:
- Evaluate abnormal areas when mammogram or ultrasound results are inconclusive
- Detect hereditary breast cancer in high-risk individuals (e.g., BRCA1 or BRCA2 mutations)
- Investigate nipple discharge or suspected distant metastases
- Screen people with dense breasts, as it may detect cancers missed by mammograms
PET (Positron Emission Tomography) Scan
A PET scan uses a small amount of radioactive material to take detailed pictures of how your organs and tissues are working. Cancer cells often absorb more of this material than normal cells, so areas with cancer show up more clearly on the scan.
PET scans are not commonly used to diagnose or stage early breast cancer (stage I or II). It may be recommended if:
Wait times for imaging vary. Ask your doctor about referral timelines or cancellation lists.
Biopsy
A biopsy removes a sample of breast tissue or cells for examination under a microscope. It is the only definitive way to confirm breast cancer. The type of biopsy performed depends on whether the abnormal area is palpable (can be felt) or non-palpable (detected only through imaging).
Types of breast biopsies include:
- Fine Needle Aspiration (FNA): Uses a thin needle to extract fluid or cells, often to determine if a lump is a cyst or solid mass. However, it cannot confirm if cancer is invasive.
- Core-Needle Biopsy: Uses a thin, hollow needle to remove small tissue samples, often guided by imaging such as ultrasound, mammography, or MRI.
- Stereotactic Core Biopsy: Uses 3D imaging to precisely locate and sample an abnormality that is visible on imaging but cannot be felt.
- Vacuum-Assisted Core Biopsy: A variation of core-needle biopsy that uses suction to remove a larger tissue sample.
- Wire Localization Biopsy: Involves placing a thin wire into an abnormal breast area using mammography to guide a surgical biopsy.
- Punch Biopsy: Uses a hollow instrument to remove a sample of skin and underlying tissue, often to diagnose inflammatory breast cancer.
- Surgical (Open) Biopsy: A surgeon removes part or all of a suspicious lump for further analysis. This includes:
- Excisional Biopsy: Removes the entire abnormal area along with a margin of healthy tissue.
- Incisional Biopsy: Removes only a portion of the abnormal area for examination.
Types of lymph node biopsies include:
- Sentinel Lymph Node Biopsy (SLNB): Identifies and removes the first lymph node(s) where cancer is likely to spread. Additional nodes are removed only if cancer is detected.
- Axillary Lymph Node Dissection (ALND): Removes multiple lymph nodes under the arm to assess cancer spread, typically when cancer has already been found in the lymph nodes.
Your healthcare provider will determine the most appropriate biopsy method based on the size, location, and characteristics of the abnormal area.
Biopsy Results & Follow-Up
Biopsy results are usually available within 7 days and provide important details such as:
- Cell type and grade – Helps determine how aggressive the cancer is.
- Hormone receptor status (ER, PR, HER2) – Guides treatment options.
Read more about what is included in a pathology report here.
If further staging is needed, your doctor may recommend additional imaging, such as a chest X-ray, CT scan, or bone scan, to assess whether cancer has spread.
Medical Review by Roochi Arora, MD, FRCPC, August 2025